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KMID : 0356619960110020182
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Journal of Korean Society of Endocrinology
1996 Volume.11 No. 2 p.182 ~ p.188
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Graves' disease associated with Hashimoto's thyroiditis
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홍성빈
김명식/이관우/김미림/인현호/김경래/조영업/주영채
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Abstract
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Hashimoto's thyroiditis and Graves' disease have been thought to be the autoimmune disease having their distinct and separate clinical and pathologic features. Because of the partial and complete similarity in histologic feature, it has been
hypothesized that Hashimoto's thyroiditis and Graves' disease may be interrelated. Several patients who had been diagnosed as Graves' disease showed features of hypothyroidism, and were proven to have histologic features of Hashimoto's
thyroiditis
in
their thyroid tissue. Two mechanisms had been suggested to explain this phenomenon One is that the combined Hashimoto's thyroiditis in Graves' disease may become predominant with time. The other is that the amount of TSH receptor blocking
antibody
may
increase in the course of Graves' disease. Early recognition of these patients would be important to estabilish therapeutic plan. Futhermore, extensive study of these patients would give more understanding of the mechanism of these diseases.
Here we report 5 cases of clinically diagnosed Graves' disease with pathologic features of Hashimoto's thyroditis or focal lymphocytic thyroiditis(J Kor Soc Endocrinol 11 : 182 ~ 188, 1996).
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KEYWORD
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